The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Angiotensin-converting enzyme 2 (ACE2) is a newly discovered carboxy-peptidase
responsible for the formation of vasodilatory peptides such as angiotensin-(1–7). We …

The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

The renin-angiotensin system is a major physiological regulator of arterial pressure and
hydro-electrolyte balance. Evidence has now been accumulated that in addition to …

Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …

This review focuses on the dysfunction of the intrinsic brain renin–angiotensin system (RAS)
in the pathogenesis of hypertension. Hyperactivity of the brain RAS plays a critical role in …

Angiotensin-(1–7)[ANG-(1–7)] is a recently described heptapeptide product of the renin-
angiotensin system. Because biosynthesis of ANG-(1–7) increases in animals treated with …

We determined the mechanism accounting for the removal and metabolism of angiotensin-
(1–7)[Ang-(1–7)] in 21 anesthetized spontaneously hypertensive (SHR), 18 age-matched …

The baroreceptor reflex is a relatively high gain control system that maintains arterial
pressure within normal limits. To a large extent, this is accomplished through central neural …