The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which
is a core symptom of depression. Accumulating studies suggest that gut microbiota may play …

Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …

Anhedonia is a common, persistent, and disabling condition. However, available
therapeutics primarily focus on the reduction of depressive and negative symptoms rather …

Neuropathic pain is a chronic painful disease. Data have shown that reactive oxygen
species (ROS) are implicated in chronic pain. Particularly, the enhanced ROS production …

Objective Anhedonia is a core symptom of major depressive disorder (MDD) and often
associated with poor prognosis. The main objective of the present study was to explore the …

Background Anhedonia, as the core endophenotype of major depressive disorder (MDD), is
closely related to poor prognosis, but the mechanism of this feature remains to be …

Our previous work indicated that ER-phagy level had altered in spinal nerve ligation (SNL)
rats. In this study, we investigated whether dexmedetomidine or ketamine exhibits anti …

Close connections between depression and type 2 diabetes (T2DM) have been suggested
by many epidemiological and experimental studies. Disturbances in insulin sensitivity due to …