Lung cancer (LC) is the leading cause of cancer death in men worldwide and has
significantly increased in women. Differences in non-small cell lung cancer (NSCLC) …

It is becoming increasingly clear that steroid hormones are involved in the biology of many
organs outside the reproductive system. Evidence has been accumulating since the mid …

Objectives Dichloroacetate (DCA) is a highly bioavailable small molecule that inhibits
pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic …

Simple Summary Exogenous and endogenous estrogens and associated receptors
modulate signaling pathways with biochemical events implicated in non-small cell lung …

G-protein-coupled estrogen receptor (GPER) was found to promote non-small cell lung
cancer (NSCLC) by estrogen, indicating the potential necessity of inhibiting GPER by a …

Estrogen classically drives lung cancer development via estrogen receptor β (ERβ).
However, fulvestrant, an anti-estrogen-based endocrine therapeutic treatment, shows limited …

Background There is accumulating epidemiological and preclinical evidence that estrogen
might be a driver of lung cancer. Breast cancer survivors can offer a unique patient cohort to …

The estrogen signaling pathway is involved in the biology of non-small-cell lung cancer and
represents a novel therapeutic target for lung cancer. This is supported by epidemiological …

Experimental and population-based evidence has been steadily accumulating that steroid
hormones are fundamentally involved in the biology of the lung. Both estrogen and …

There is growing evidence that estrogen receptors (ER) are expressed in lung cancer cells,
and are able to interact with the epidermal growth factor receptor (EGFR) signaling pathway …