CKD is common and frequently complicated with hypertension both predialysis and in
ESKD. As a major modifiable risk factor for cardiovascular disease in this high-risk …

Background: Primary aldosteronism is recognized as a severe form of renin-independent
aldosteronism that results in excessive mineralocorticoid receptor (MR) activation. Objective …

Pathophysiologically lower BPs results in less strain on the LV, and, thus, more aggressive
BP control may have benefits in terms of LV hypertrophy, myocardial fibrosis, diastolic …

Background and aim Considering the amount of novel knowledge generated in the last five
years, a team of experienced hypertensionlogists was assembled to furnish updated clinical …

ABSTRACT Background Mineralocorticoid receptor antagonists (MRAs) reduce systolic
blood pressure (SBP) and increase serum potassium concentration ([K+]). This indirect …

Glomerular disease, including nephrotic syndrome and nephritic syndrome, is the third
leading cause of end-stage kidney disease (ESKD) in the United States after diabetes …

Hypertensive individuals are at an increased risk of developing heart disease and stroke.
Adopting healthy lifestyles, such as being active on≥ 4 days per week, weight-loss in the …

Baxdrostat is a selective inhibitor of aldosterone synthase designed for the treatment of
disorders associated with elevated aldosterone. This study evaluated the safety …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking
luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct …