Physiological and regulatory convergence between osmotic and nutrient stress responses in microbes

AM Brauer, H Shi, PA Levin, KC Huang - Current Opinion in Cell Biology, 2023 - Elsevier
Bacterial cells are regularly confronted with simultaneous changes in environmental nutrient
supply and osmolarity. Despite the importance of osmolarity and osmoregulation in bacterial …

Trehalose and bacterial virulence

M Vanaporn, RW Titball - Virulence, 2020 - Taylor & Francis
Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage,
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …

Effects of NaCl Concentrations on Growth Patterns, Phenotypes Associated With Virulence, and Energy Metabolism in Escherichia coli BW25113

F Li, XS Xiong, YY Yang, JJ Wang, MM Wang… - Frontiers in …, 2021 - frontiersin.org
According to the sit-and-wait hypothesis, long-term environmental survival is positively
correlated with increased bacterial pathogenicity because high durability reduces the …

Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment

S Monem, B Furmanek-Blaszk, A Łupkowska… - International Journal of …, 2020 - mdpi.com
Acinetobacter baumannii is considered one of the most persistent pathogens responsible for
nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high …

Unraveling the Molecular Mechanisms of Trehalose-Mediated Protection and Stabilization of Escherichia coli Lipid Membrane during Desiccation

A Maiti, S Daschakraborty - The Journal of Physical Chemistry B, 2023 - ACS Publications
Trehalose, a disaccharide renowned for its ability to stabilize biomolecular architectures
under strenuous conditions, finds extensive use in the cryopreservation of probiotics. A …

Mechanism of validamycin A inhibiting DON biosynthesis and synergizing with DMI fungicides against Fusarium graminearum

C Bian, Y Duan, Q Xiu, J Wang, X Tao… - Molecular Plant …, 2021 - Wiley Online Library
Deoxynivalenol (DON) is a vital virulence factor of Fusarium graminearum, which causes
Fusarium head blight (FHB). We recently found that validamycin A (VMA), an …

New insight into the mechanisms protecting bacteria during desiccation

E Laskowska, D Kuczyńska-Wiśnik - Current genetics, 2020 - Springer
Desiccation is a common stress that bacteria face in the natural environment, and thus, they
have developed a variety of protective mechanisms to mitigate the damage caused by water …

Intracellular Protective Functions and Therapeutical Potential of Trehalose

D Kuczyńska-Wiśnik, K Stojowska-Swędrzyńska… - Molecules, 2024 - mdpi.com
Trehalose is a naturally occurring, non-reducing saccharide widely distributed in nature.
Over the years, research on trehalose has revealed that this initially thought simple storage …

[HTML][HTML] Protein aggregation and glycation in Escherichia coli exposed to desiccation-rehydration stress

A Łupkowska, S Monem, J Dębski… - Microbiological …, 2023 - Elsevier
In natural environments, bacteria often enter a state of anhydrobiosis due to water loss.
Multiple studies have demonstrated that desiccation may lead to protein aggregation and …

Liquid–Liquid Phase Separation and protective protein aggregates in bacteria

D Kuczyńska-Wiśnik, K Stojowska-Swędrzyńska… - Molecules, 2023 - mdpi.com
Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles
(MLOs) contribute to the spatiotemporal organization of various physiological processes in …