E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse
gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an …

Gastric cancer is the third-most fatal cancer in the world. Though over the years, we saw
patients mostly with intestinal type accounting for the highest mortality rate, the recent rise of …

Hereditary diffuse gastric cancer (HDGC), comprising 1%–3% of gastric malignances, has
been associated with CDH1 variants. Accumulating evidence has demonstrated more than …

Mutations in the CDH1 gene are the genetic hallmark of hereditary diffuse gastric cancer
(HDGC), a cancer syndrome characterised by high rates of both diffuse gastric cancer and …

CDH1 gene mutation carriers have to deal with a significant emotional burden associated
with the increased risk of developing invasive and aggressive cancer, difficulties in …

The article presents a case studies of three patients including 37‐year‐old female patient
asked for a bilateral risk‐reducing mastectomy (RRM), oncologists and Gynecologists of our …

Background What is the etiology of skin tags? What factors are involved in the patho-
biochemistry of combined skin tags and internal malignancy? This study aimed to assess the …

Genetic counselors in the cancer setting are subjected to the repeat exposure of discussing
severe management recommendations for individuals who test positive for pathogenic …

Los antecedentes familiares son una parte muy importante del riesgo de cáncer de mama.
Aproximadamente el 5-10% de los casos de cáncer de mama son hereditarios. El cáncer …

Family history is a very important part of breast cancer risk. About 5-10% of breast cancer
cases are hereditary. Hereditary cancer happens when changes or mutations in genes are …