Assessment and maintenance of end-organ perfusion are key to resuscitation in critical
illness, although there are limited direct methods or proxy measures to assess cerebral …

Introduction: Cerebral autoregulation (CA) plays a fundamental role in the maintenance of
adequate cerebral blood flow (CBF). CA monitoring, through direct and indirect techniques …

Background Sepsis-associated brain dysfunction (SABD) is associated with high morbidity
and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired …

Cerebral blood flow (CBF) autoregulation maintains consistent blood flow across a range of
blood pressures (BPs). Sepsis is a common cause of systemic hypotension and cerebral …

Background: Impaired cerebral autoregulation and cerebral hypoperfusion may play a
critical role in the high morbidity and mortality in patients with sepsis-associated …

Background Alteration of the mechanisms of cerebral blood flow (CBF) regulation might
contribute to the pathophysiology of sepsis-associated encephalopathy (SAE). However …

Introduction Dynamic cerebral autoregulation (dCA) is frequently altered in patients with
sepsis and may be associated with sepsis-associated brain dysfunction. However, the …

Uncontrolled vasodilation is known to account for hypotension in the advanced stages of
sepsis and other systemic inflammatory conditions, but the mechanisms of hypotension in …

In sepsis, higher PaCO2 levels are associated with impaired dynamic cerebral
autoregulation (dCA), which may expose the brain to hypo-and hyperperfusion during acute …

Aim: The aim of this study was to investigate the effects of different vasopressors on the
cerebral vasculature during experimental human endotoxemia and sepsis. We used the …