Impact of membrane drug transporters on resistance to small-molecule tyrosine kinase inhibitors
C Neul, E Schaeffeler, A Sparreboom, S Laufer… - Trends in …, 2016 - cell.com
Small-molecule inhibitors of tyrosine kinases (TKIs) are the mainstay of treatment for many
malignancies and represent novel treatment options for other diseases such as idiopathic …
malignancies and represent novel treatment options for other diseases such as idiopathic …
The histone variant H2A. Z is an important regulator of enhancer activity
M Brunelle, A Nordell Markovits… - Nucleic acids …, 2015 - academic.oup.com
Gene regulatory programs in different cell types are largely defined through cell-specific
enhancers activity. The histone variant H2A. Z has been shown to play important roles in …
enhancers activity. The histone variant H2A. Z has been shown to play important roles in …
Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
JAY Roubroeks, RG Smith… - Journal of …, 2017 - Wiley Online Library
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …
various neurodegenerative diseases. In this review, we discuss advances that have been …
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics
White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …
[HTML][HTML] DNA methylation, nuclear organization, and cancer
BP Madakashira, KC Sadler - Frontiers in genetics, 2017 - frontiersin.org
The dramatic re-organization of the cancer cell nucleus creates telltale morphological
features critical for pathological staging of tumors. In addition, the changes to the mutational …
features critical for pathological staging of tumors. In addition, the changes to the mutational …
Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes
ND VanderKraats, JF Hiken, KF Decker… - Nucleic acids …, 2013 - academic.oup.com
Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a
generally accepted mechanism for silencing expression. While recent technological …
generally accepted mechanism for silencing expression. While recent technological …
[HTML][HTML] DNA methylation and de-methylation using hybrid site-targeting proteins
DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …
environmental responses, but little is known about the mechanisms that drive methylation …
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells
Y Cai, HC Tsai, RWC Yen, YW Zhang, X Kong… - Genome …, 2017 - genome.cshlp.org
Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting
DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm …
DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm …
Flow-dependent epigenetic DNA methylation in endothelial gene expression and atherosclerosis
Epigenetic mechanisms that regulate endothelial cell gene expression are now emerging.
DNA methylation is the most stable epigenetic mark that confers persisting changes in gene …
DNA methylation is the most stable epigenetic mark that confers persisting changes in gene …
[PDF][PDF] Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9
activation (CRISPRa) systems have enabled genetic screens in cultured cell lines to …
activation (CRISPRa) systems have enabled genetic screens in cultured cell lines to …