Small-molecule inhibitors of tyrosine kinases (TKIs) are the mainstay of treatment for many
malignancies and represent novel treatment options for other diseases such as idiopathic …

Gene regulatory programs in different cell types are largely defined through cell-specific
enhancers activity. The histone variant H2A. Z has been shown to play important roles in …

Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …

The dramatic re-organization of the cancer cell nucleus creates telltale morphological
features critical for pathological staging of tumors. In addition, the changes to the mutational …

Methylation of the CpG-rich region (CpG island) overlapping a gene's promoter is a
generally accepted mechanism for silencing expression. While recent technological …

DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …

Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting
DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm …

Epigenetic mechanisms that regulate endothelial cell gene expression are now emerging.
DNA methylation is the most stable epigenetic mark that confers persisting changes in gene …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9
activation (CRISPRa) systems have enabled genetic screens in cultured cell lines to …