Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated 9
activation (CRISPRa) systems have enabled genetic screens in cultured cell lines to …

Hepatitis virus infection is a leading cause of chronic liver disease, including cirrhosis and
hepatocellular carcinoma (HCC). Although anti-viral therapies against hepatitis B virus …

Background The complex composition of different cell types within a tissue can be estimated
by deconvolution of bulk gene expression profiles or with various single-cell sequencing …

Glioblastoma (GBM) is the most common and most aggressive primary brain tumor in adults.
The existence of a small population of stem-like tumor cells that efficiently propagate tumors …

DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of
which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to …

In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …

A neuron is unique in its ability to dynamically modify its transcriptional output in response to
synaptic activity while maintaining a core gene expression program that preserves cellular …

Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …

The establishment of synaptic plasticity and long-term memory requires lasting cellular and
molecular modifications that, as a whole, must endure despite the rapid turnover of their …

DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …