Whole-genome fingerprint of the DNA methylome during human B cell differentiation
We analyzed the DNA methylome of ten subpopulations spanning the entire B cell
differentiation program by whole-genome bisulfite sequencing and high-density microarrays …
differentiation program by whole-genome bisulfite sequencing and high-density microarrays …
Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA
SY Shen, JM Burgener, SV Bratman… - Nature protocols, 2019 - nature.com
Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and
tumor tissue that are released into the bloodstream. Recently, methylation profiling of cfDNA …
tumor tissue that are released into the bloodstream. Recently, methylation profiling of cfDNA …
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Developmental tumors in children and young adults carry few genetic alterations, yet they
have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the …
have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the …
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …
increases most aspects of health during aging and extends lifespan in diverse species …
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment
S Cooper, M Dienstbier, R Hassan, L Schermelleh… - Cell reports, 2014 - cell.com
The mechanisms by which the major Polycomb group (PcG) complexes PRC1 and PRC2
are recruited to target sites in vertebrate cells are not well understood. Building on recent …
are recruited to target sites in vertebrate cells are not well understood. Building on recent …
[PDF][PDF] Distinct properties of cell-type-specific and shared transcription factor binding sites
Most human transcription factors bind a small subset of potential genomic sites and often
use different subsets in different cell types. To identify mechanisms that govern cell-type …
use different subsets in different cell types. To identify mechanisms that govern cell-type …
[HTML][HTML] Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …
[HTML][HTML] The molecular basis of MeCP2 function in the brain
R Tillotson, A Bird - Journal of molecular biology, 2020 - Elsevier
MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome
due to its high abundance and the frequency of its target sites. It has been the subject of …
due to its high abundance and the frequency of its target sites. It has been the subject of …
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
DNA methylation is essential for mammalian development and physiology. Here we report
that the developmentally regulated H19 lncRNA binds to and inhibits S …
that the developmentally regulated H19 lncRNA binds to and inhibits S …