[HTML][HTML] Metformin alters DNA methylation genome-wide via the H19/SAHH axis
The molecular mechanisms underlying the antineoplastic properties of metformin, a first-line
drug for type 2 diabetes, remain elusive. Here we report that metformin induces genome …
drug for type 2 diabetes, remain elusive. Here we report that metformin induces genome …
[HTML][HTML] Homeobox oncogene activation by pan-cancer DNA hypermethylation
Background Cancers have long been recognized to be not only genetically but also
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …
Epigenetics, development, and psychopathology
KJ O'Donnell, MJ Meaney - Annual Review of Clinical …, 2020 - annualreviews.org
Epigenetic mechanisms govern the transcription of the genome. Research with model
systems reveals that environmental conditions can directly influence epigenetic mechanisms …
systems reveals that environmental conditions can directly influence epigenetic mechanisms …
[HTML][HTML] Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
Genome-wide association studies (GWAS) have identified~ 20 melanoma susceptibility loci,
most of which are not functionally characterized. Here we report an approach integrating …
most of which are not functionally characterized. Here we report an approach integrating …
[HTML][HTML] Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease
Background Alzheimer's disease is a progressive neurodegenerative disorder that is
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …
hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in …
[HTML][HTML] Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines
E Papp, D Hallberg, GE Konecny, DC Bruhm, V Adleff… - Cell reports, 2018 - cell.com
To improve our understanding of ovarian cancer, we performed genome-wide analyses of
45 ovarian cancer cell lines. Given the challenges of genomic analyses of tumors without …
45 ovarian cancer cell lines. Given the challenges of genomic analyses of tumors without …
[HTML][HTML] DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells
Promoter DNA methylation is a key epigenetic mechanism for stable gene silencing, but is
correlated with expression when located in gene bodies. Maintenance and de novo DNA …
correlated with expression when located in gene bodies. Maintenance and de novo DNA …
[HTML][HTML] A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
G Sendžikaitė, CW Hanna, KR Stewart-Morgan… - Nature …, 2019 - nature.com
DNA methyltransferases (DNMTs) deposit DNA methylation, which regulates gene
expression and is essential for mammalian development. Histone post-translational …
expression and is essential for mammalian development. Histone post-translational …
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
J Viana, E Hannon, E Dempster… - Human molecular …, 2017 - academic.oup.com
Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …
Exercise: putting action into our epigenome
Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …