Background The liver plays a central role in the maintenance of homeostasis and health in
general. However, there is substantial inter-individual variation in hepatic gene expression …

DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents
an important regulatory layer associated with gene expression. Changed methylation status …

DNA methyltransferase inhibitors (DNMTi) approved for older AML patients are clinically
tested in combination with histone deacetylase inhibitors (HDACi). The mechanism of action …

Active DNA demethylation is critical for controlling the DNA methylomes in plants and
mammals. However, little is known about how DNA demethylases are recruited to target loci …

It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects
of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative …

The etiopathogenesis of sporadic Parkinson's disease (PD) remains elusive although
mitochondrial dysfunction has long been implicated. Recent evidence revealed reduced …

Epigenetic alterations are increasingly recognized as mechanisms for disease-associated
changes in genome function and important risk factors for complex diseases. The …

White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …

A growing number of epigenome-wide association studies have demonstrated a role for
DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral …

It is widely accepted that the epigenome can act as the link between environmental cues,
both external and internal, to the organism and phenotype by converting the environmental …