The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
TERT—regulation and roles in cancer formation
M Dratwa, B Wysoczańska, P Łacina, T Kubik… - Frontiers in …, 2020 - frontiersin.org
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …
complex plays a key role in cancer formation by telomere dependent or independent …
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
KP Guillen, M Fujita, AJ Butterfield, SD Scherer… - Nature cancer, 2022 - nature.com
Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived …
develop more effective cancer therapies. We report a bank of human patient-derived …
An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
Parallel single-cell sequencing protocols represent powerful methods for investigating
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …
regulatory relationships, including epigenome-transcriptome interactions. Here, we report a …
[HTML][HTML] Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …
association with human disease, but epigenomic studies lack a similar reference. To …
Mechanisms of hypoxia signalling: new implications for nephrology
J Schödel, PJ Ratcliffe - Nature Reviews Nephrology, 2019 - nature.com
Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …
the classical physiological responses to hypoxia, led to the discovery of human oxygen …
DNA methylation pathways and their crosstalk with histone methylation
J Du, LM Johnson, SE Jacobsen… - Nature reviews Molecular …, 2015 - nature.com
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …
[PDF][PDF] Gene body methylation can alter gene expression and is a therapeutic target in cancer
DNA methylation in promoters is well known to silence genes and is the presumed
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …