[HTML][HTML] A global review on short peptides: frontiers and perspectives
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …
entities via all domains of life and interfere with protein-protein interactions, which are …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Modular diazo compound for the bioreversible late-stage modification of proteins
We introduce a versatile strategy for the bioreversible modification of proteins. Our strategy
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …
Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases
Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …
[HTML][HTML] Nanoparticles modified with cell-penetrating peptides: Conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and …
I Gessner, I Neundorf - International journal of molecular sciences, 2020 - mdpi.com
Based on their tunable physicochemical properties and the possibility of producing cell-
specific platforms through surface modification with functional biomolecules, nanoparticles …
specific platforms through surface modification with functional biomolecules, nanoparticles …
Cell-penetrating peptides (CPPs): An overview of applications for improving the potential of nanotherapeutics
In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell
continues to be an ultimate challenge. There are many physicochemical factors such as …
continues to be an ultimate challenge. There are many physicochemical factors such as …
Cell penetrating peptides: The potent multi-cargo intracellular carriers
ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …
[HTML][HTML] Cell penetrating peptides, novel vectors for gene therapy
Cell penetrating peptides (CPPs), also known as protein transduction domains (PTDs), first
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …
identified~ 25 years ago, are small, 6–30 amino acid long, synthetic, or naturally occurring …
[HTML][HTML] Membrane active peptides and their biophysical characterization
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …
active peptides. These peptides exert their biological activity by interacting with the cell …
[HTML][HTML] Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
S Yu, H Yang, T Li, H Pan, S Ren, G Luo, J Jiang… - Nature …, 2021 - nature.com
Protein delivery with cell-penetrating peptide is opening up the possibility of using targets
inside cells for therapeutic or biological applications; however, cell-penetrating peptide …
inside cells for therapeutic or biological applications; however, cell-penetrating peptide …