Experimental autoimmune encephalomyelitis (EAE) is a mouse model that can be used to
investigate aetiology, pathogenesis, and treatment approaches for multiple sclerosis (MS). A …

Multiple sclerosis is an inflammatory, demyelinating disease of the CNS. Whereas
oligodendrocytes have been considered the primary neural cell type most affected, recent …

Multiple sclerosis, the most common cause of neurological disability in young population
after trauma, represents a significant public health burden. Current challenges associated …

Despite recent advances in the diagnosis and treatment of multiple sclerosis, we still lack a
consensus regarding the causes, pathogenesis, and mechanisms of disease progression …

Multiple sclerosis (MS) is a progressive, demyelinating inflammatory disease of the human
central nervous system (CNS). While the primary symptoms of MS affect motor function, it is …

Growing evidence suggests that mast cells (MCs) play a crucial role in the inflammatory
process and the subsequent demyelination observed in patients suffering from multiple …

Parvalbumin (PV) and calretinin (CR) are calcium binding proteins (CBP's) expressed in
discrete GABAergic interneuron populations in the human cortex. CBP's are known to buffer …

Uncoupling protein 2 (UCP2) is a member of the mitochondrial transporter superfamily that
is expressed in many tissues, including immune cells. UCP2 prevents oxidative stress by …

The glial cell line-derived neurotrophic factor (GDNF) is involved in the development and
maintenance of neural tissues. Mutations in components of its signaling pathway lead to …

Experimental autoimmune encephalomyelitis (EAE) is a well-recognized model for multiple
sclerosis (MS) in humans. However, adjuvants used with encephalitogens to induce EAE …