In vitro and ex vivo models for evaluating vaginal drug delivery systems

RL Shapiro, K DeLong, F Zulfiqar, D Carter… - Advanced drug delivery …, 2022 - Elsevier
Vaginal drug delivery systems are often preferred for treating a variety of diseases and
conditions of the female reproductive tract (FRT), as delivery can be more targeted with less …

Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

[HTML][HTML] Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses

J Li, S Deng, J Li, L Li, F Zhang, Y Zou, D Wu… - Cellular & molecular …, 2022 - Springer
Background Acute lung injury (ALI) has received considerable attention in the field of
intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in …

Mucus penetration of surface-engineered nanoparticles in various pH microenvironments

Y Guo, Y Ma, X Chen, M Li, X Ma, G Cheng, C Xue… - ACS …, 2023 - ACS Publications
The penetration behavior of nanoparticles in mucous depends on physicochemical
properties of the nanoparticles and the mucus microenvironment, due to particle–mucin …

[HTML][HTML] Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway

L Lou, M Wang, J He, S Yang, F Meng… - Frontiers in …, 2023 - frontiersin.org
Acute lung injury (ALI) is a life-threatening disease with high incidence and mortality rates.
Urolithin A (UA) is a pomegranate intestinal flora metabolite with anti-inflammatory …

[HTML][HTML] Protectin conjugates in tissue regeneration 1 alleviates sepsis-induced acute lung injury by inhibiting ferroptosis

Y Lv, D Chen, X Tian, J Xiao, C Xu, L Du, J Li… - Journal of translational …, 2023 - Springer
Background Acute lung injury (ALI) is a common and serious complication of sepsis with
high mortality. Ferroptosis, categorized as programmed cell death, contributes to the …

[HTML][HTML] Antibacterial and antibiofilm activities of ZIF-67

R Gallegos-Monterrosa, RO Mendiola, Y Nuñez… - The Journal of …, 2023 - nature.com
Currently, antibiotic-resistant bacteria represent a serious threat to public health worldwide.
Biofilm formation potentiates both virulence and antibiotic resistance of bacteria. Therefore …

[HTML][HTML] Organoid factory: The recent role of the human induced pluripotent stem cells (hiPSCs) in precision medicine

G Novelli, P Spitalieri, M Murdocca… - Frontiers in Cell and …, 2023 - frontiersin.org
During the last decades, hiPSC-derived organoids have been extensively studied and used
as in vitro models for several applications among which research studies. They can be …

[HTML][HTML] NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1, 3-dichloropropene

M Moreau, J Fisher, ME Andersen, A Barnwell… - Toxicology, 2022 - Elsevier
Time, cost, ethical, and regulatory considerations surrounding in vivo testing methods render
them insufficient to meet existing and future chemical safety testing demands. There is a …

[HTML][HTML] S100A9-/-alleviates LPS-induced acute lung injury by regulating M1 macrophage polarization and inhibiting pyroptosis via the TLR4/MyD88/NFκB signaling …

C Gong, J Ma, Y Deng, Q Liu, Z Zhan, H Gan… - Biomedicine & …, 2024 - Elsevier
Acute lung injury (ALI) is characterized by pulmonary diffusion abnormalities that may
progress to multiple-organ failure in severe cases. There are limited effective treatments for …