[HTML][HTML] Ovariectomized rat model of osteoporosis: a practical guide

N Yousefzadeh, K Kashfi, S Jeddi, A Ghasemi - EXCLI journal, 2020 - ncbi.nlm.nih.gov
Osteoporosis affects about 200 million people worldwide and is a silent disease until a
fracture occurs. Management of osteoporosis is still a challenge that warrants further studies …

[HTML][HTML] Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

S Caddeo, M Boffito, S Sartori - Frontiers in bioengineering and …, 2017 - frontiersin.org
In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …

The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration

L Mao, L Xia, J Chang, J Liu, L Jiang, C Wu, B Fang - Acta biomaterialia, 2017 - Elsevier
Bioactive ions released from bioceramics play important roles in bone regeneration;
however, it is unclear how each ionic composition in complex bioceramics exerts its specific …

The effect of icariin on bone metabolism and its potential clinical application

Z Wang, D Wang, D Yang, W Zhen, J Zhang… - Osteoporosis …, 2018 - Springer
Osteoporosis is a bone disease characterized by reduced bone mass, which leads to
increased risk of bone fractures, and poses a significant risk to public health, especially in …

The laboratory rat as an animal model for osteoporosis research

PP Lelovas, TT Xanthos, SE Thoma… - Comparative …, 2008 - ingentaconnect.com
Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a
diverse and multifactorial etiology. A large variety of animal species, including rodents …

Cortical bone porosity: what is it, why is it important, and how can we detect it?

DML Cooper, CE Kawalilak, K Harrison… - Current osteoporosis …, 2016 - Springer
There is growing recognition of the role of micro-architecture in osteoporotic bone loss and
fragility. This trend has been driven by advances in imaging technology, which have …

Alcohol: a simple nutrient with complex actions on bone in the adult skeleton

GW Gaddini, RT Turner, KA Grant… - Alcoholism: clinical …, 2016 - Wiley Online Library
Background Alcohol is an important nonessential component of diet, but the overall impact
of drinking on bone health, especially at moderate levels, is not well understood. Bone …

[HTML][HTML] Pharmaceutical treatment of bone loss: From animal models and drug development to future treatment strategies

MB Brent - Pharmacology & Therapeutics, 2023 - Elsevier
Animal models are fundamental to advance our knowledge of the underlying
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …

Phytosterols protect against osteoporosis by regulating gut microbiota

X Xiao, J Wang, Y Zhu, B Deng, Y Liu… - Journal of agricultural …, 2023 - ACS Publications
Osteoporosis is increasingly prevalent worldwide, representing a major health burden.
However, there is a lack of nutritional strategies for osteoporotic therapy. Phytosterols, as …

The rational use of animal models in the evaluation of novel bone regenerative therapies

M Peric, I Dumic-Cule, D Grcevic, M Matijasic… - Bone, 2015 - Elsevier
Bone has a high potential for endogenous self-repair. However, due to population aging,
human diseases with impaired bone regeneration are on the rise. Current strategies to …