The immune system is strongly linked to the maintenance of healthy bone. Inflammatory
cytokines, specifically, are crucial to skeletal homeostasis and any dysregulation can result …

Proteasome inhibitors (PIs) are a fascinating class of small molecules that disrupt protein
homeostasis and are highly efficacious in the blood cancer multiple myeloma. However, PIs …

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might
influence whether a cell is sensitive or resistant to a certain drug. So far, only a limited …

Identification of multidrug (MDR) efflux transporters that belong to the ATP-Binding Cassette
(ABC) superfamily, represented an important breakthrough for understanding cancer …

Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-
galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in …

Simple Summary The bone marrow (BM) microenvironment provides a protective sanctuary
for multiple myeloma (MM) against therapeutic agents. MM cells interact with BM stromal …

Proteasome inhibitors, such as bortezomib (BTZ), represent the key elements in
chemotherapy regimens for multiple myeloma (MM), whereas acquired chemoresistance …

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical
outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in …

The microsporidia Nosema ceranae is an obligate intracellular parasite that causes honey
bee mortality and contributes to colony collapse. Fumagillin is presently the only …

Multiple myeloma (MM) remains an incurable, genetically heterogeneous disease
characterized by the uncontrolled proliferation of transformed plasma cells nurtured within a …