The intestine is the largest peripheral lymphoid organ in animals, including humans, and
interacts with a vast array of microorganisms called the gut microbiota. Comprehending the …

Beyond their conventional roles in intracellular energy production, some traditional
metabolites also function as extracellular messengers that activate cell-surface G-protein …

Neuronal activity undergoes significant changes during vigilance states, accompanied by an
accommodation of energy demands. While the astrocyte-neuron lactate shuttle has shown …

White adipose tissue browning, defined by accelerated mitochondrial metabolism and
biogenesis, is considered a promising mean to treat or prevent obesity-associated metabolic …

High levels of plasma lactate are associated with increased mortality in critically injured
patients, including those with severe burns. Although lactate has long been considered a …

Abstract Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-
related death, but the underlying mechanism driving cachexia remains elusive. Here we …

Background The appetite-suppressing potential of liver-expressed antimicrobial peptide 2
(LEAP2), and its antagonistic effects on the hunger-inducing hormone ghrelin have attracted …

High‐intensity exercise stimulates glycolysis, subsequently leading to elevated lactate
production within skeletal muscle. While lactate produced within the muscle is …

In a recent study published in Nature, Liu and co-workers show that high lactate production
by tumor cells promotes premature mitotic escape and further cell proliferation by facilitating …

TO THE EDITOR: Browning of white fat following burn injuries is a well-known phenomenon
(1). A new article by Barayan et al.(2) suggests that this effect is driven by lactate shuttling. In …