Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be
assessed only in observational studies. We performed a systematic review of prospective …

Objective: To update the practice parameters for the evaluation of adult patients who
develop a new fever in the intensive care unit, for the purpose of guiding clinical practice …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Objectives: Delayed antimicrobials are associated with poor outcomes in adult sepsis, but
data relating antimicrobial timing to mortality and organ dysfunction in pediatric sepsis are …

Background Timely administration of antibiotics is one of the most important interventions in
reducing mortality in sepsis. However, administering antibiotics within a strict time threshold …

Here we describe a blood-cleansing device for sepsis therapy inspired by the spleen, which
can continuously remove pathogens and toxins from blood without first identifying the …

The extreme pharmacokinetic behaviour of drugs sometimes observed in critically ill patients
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …

Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

Abstract The Surviving Sepsis Campaign recommends immediate antibiotics for all patients
with suspected sepsis and septic shock, ideally within 1 hour of recognition. Immediate …

Bacterial sepsis is a serious clinical condition that can lead to multiple organ dysfunction
and death despite timely treatment with antibiotics and fluid resuscitation. We have …