The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

Abstract 3D printing, also known as Additive manufacturing (AM), has emerged as a
transformative technology with applications across various industries, including the medical …

Angiogenesis has an essential role in tumor growth and metastasis, and blocking this
pathway has been a successfully utilized strategy in the clinical treatment of cancer …

Acquired resistance to tyrosine kinase inhibitors (TKIs) is the major obstacle to improve
clinical efficacy in cancer patients. The epithelial-stromal interaction in tumor …

Glioblastoma (GBM) is the most common aggressive malignant tumor in brain
neuroepithelial tumors and remains incurable. A variety of treatment options are currently …

Lung cancer still contributes to nearly one‐quarter cancer‐related deaths in the past
decades, despite the rapid development of targeted therapy and immunotherapy in non …

Owing to genetic alterations and overexpression, the dysregulation of protein kinases plays
a significant role in the pathogenesis of many autoimmune and neoplastic disorders and …

Background This study evaluated the efficacy and safety of anlotinib combined with
programmed cell death protein 1 (PD-1) blockade for the treatment of small-cell lung cancer …

Purpose: Immune checkpoint inhibitors plus antiangiogenic tyrosine kinase inhibitors may
offer a first-line treatment for advanced hepatocellular carcinoma (HCC). In this phase 2 trial …

Abstract Anlotinib (AL3818), a novel multi-targeted receptor tyrosine kinase inhibitor, has
recently been proven to be an antitumour drug. This study aimed to explore the antitumour …