A CAPE analogue as novel antiplatelet agent efficiently inhibits collagen-induced platelet aggregation
K Zhou, X Li, Q Du, D Li, M Hu, X Yang… - Die Pharmazie-An …, 2014 - ingentaconnect.com
Objective: Platelet activation plays a pivotal role in the pathogenesis of thrombosis, which
can lead to fatal diseases such as myocardial or cerebral infarction, and atherosclerosis …
can lead to fatal diseases such as myocardial or cerebral infarction, and atherosclerosis …
Activation of soluble guanylyl cyclase with inhibition of multidrug resistance protein inhibitor-4 (MRP4) as a new antiplatelet therapy
The intracellular levels of cyclic GMP are controlled by its rate of formation through nitric
oxide-mediated stimulation of soluble guanylate cyclase (sGC) and its degradation by …
oxide-mediated stimulation of soluble guanylate cyclase (sGC) and its degradation by …
[HTML][HTML] Calcium regulation on the atrial regional difference of collagen production activity in atrial fibrogenesis
CC Chung, YK Lin, YC Chen, YH Kao, YH Yeh… - Biomedicines, 2021 - mdpi.com
Background: Atrial fibrosis plays an important role in the genesis of heart failure and atrial
fibrillation. The left atrium (LA) exhibits a higher level of fibrosis than the right atrium (RA) in …
fibrillation. The left atrium (LA) exhibits a higher level of fibrosis than the right atrium (RA) in …
Volume overload induces differential spatiotemporal regulation of myocardial soluble guanylyl cyclase in eccentric hypertrophy and heart failure
Y Liu, AR Dillon, M Tillson, C Makarewich… - Journal of molecular and …, 2013 - Elsevier
Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac stress response,
including cardiomyocyte hypertrophy. In the concentric hypertrophied heart, oxidation and re …
including cardiomyocyte hypertrophy. In the concentric hypertrophied heart, oxidation and re …
Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism
Background We test if inhaled nitric oxide (NO) attenuates platelet functional and metabolic
hyper-reactivity in subjects with submassive pulmonary embolism (PE). Methods …
hyper-reactivity in subjects with submassive pulmonary embolism (PE). Methods …
[HTML][HTML] Comparative Studies of the Dynamics Effects of BAY60-2770 and BAY58-2667 Binding with Human and Bacterial H-NOX Domains
Soluble guanylate cyclase (sGC) is a key enzyme implicated in various physiological
processes such as vasodilation, thrombosis and platelet aggregation. The enzyme's Heme …
processes such as vasodilation, thrombosis and platelet aggregation. The enzyme's Heme …
[HTML][HTML] Activation of PKG and Akt is required for cardioprotection by Ramelteon-induced preconditioning and is located upstream of mKCa-channels
C Torregroza, O Jalajel, A Raupach, K Feige… - International journal of …, 2020 - mdpi.com
Ramelteon is a Melatonin 1 (MT1)—and Melatonin 2 (MT2)—receptor agonist conferring
cardioprotection by pharmacologic preconditioning. While activation of mitochondrial …
cardioprotection by pharmacologic preconditioning. While activation of mitochondrial …
Q817G mutation in phosphodiesterase type 5: Conformational analysis and dissociation profile of the inhibitor Tadalafil
I Pires de Oliveira, CH Lescano… - Chemical biology & …, 2019 - Wiley Online Library
Abstract Phosphodiesterase type 5 (PDE‐5) is an important enzyme involved in the
hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate …
hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate …
The soluble guanylyl cyclase activator BAY 60-2770 potently relaxes the pulmonary artery on congenital diaphragmatic hernia rabbit model
JA Rojas-Moscoso, E Antunes, RR Figueira… - Pediatric surgery …, 2014 - Springer
Purpose Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension
which is often difficult to manage, and a significant cause of morbidity and mortality. In this …
which is often difficult to manage, and a significant cause of morbidity and mortality. In this …
[HTML][HTML] Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti‐platelet therapy
Background Endothelium‐derived prostacyclin and nitric oxide elevate platelet cyclic
nucleotide levels and maintain quiescence. We previously demonstrated that a synergistic …
nucleotide levels and maintain quiescence. We previously demonstrated that a synergistic …