Objective: Platelet activation plays a pivotal role in the pathogenesis of thrombosis, which
can lead to fatal diseases such as myocardial or cerebral infarction, and atherosclerosis …

The intracellular levels of cyclic GMP are controlled by its rate of formation through nitric
oxide-mediated stimulation of soluble guanylate cyclase (sGC) and its degradation by …

Background: Atrial fibrosis plays an important role in the genesis of heart failure and atrial
fibrillation. The left atrium (LA) exhibits a higher level of fibrosis than the right atrium (RA) in …

Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac stress response,
including cardiomyocyte hypertrophy. In the concentric hypertrophied heart, oxidation and re …

Background We test if inhaled nitric oxide (NO) attenuates platelet functional and metabolic
hyper-reactivity in subjects with submassive pulmonary embolism (PE). Methods …

Soluble guanylate cyclase (sGC) is a key enzyme implicated in various physiological
processes such as vasodilation, thrombosis and platelet aggregation. The enzyme's Heme …

Ramelteon is a Melatonin 1 (MT1)—and Melatonin 2 (MT2)—receptor agonist conferring
cardioprotection by pharmacologic preconditioning. While activation of mitochondrial …

Abstract Phosphodiesterase type 5 (PDE‐5) is an important enzyme involved in the
hydrolysis of cyclic guanosine monophosphate (cGMP) to guanosine monophosphate …

Purpose Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension
which is often difficult to manage, and a significant cause of morbidity and mortality. In this …

Background Endothelium‐derived prostacyclin and nitric oxide elevate platelet cyclic
nucleotide levels and maintain quiescence. We previously demonstrated that a synergistic …