The COVID-19 pandemic now totaling 13,000,000 cases and over 571,000 deaths has
continued to teach the medical, scientific and lay communities about viral infectious disease …

The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular
complications characterized by thrombosis of small, medium, and large vessels. Dysfunction …

According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is
composed of glycosaminoglycans and the proteins that tether them to the plasma …

Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present
in the endothelial glycocalyx covering the apical surface of endothelial cells. The endothelial …

Purpose In 2007 the two senior authors wrote a review on the structure and function of the
endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9: 121–167, 2007). Since …

Located in the innermost layer of the vasculature and directly interacting with blood flow,
endothelium integrates various biochemical and biomechanical signals to maintain barrier …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …