Allelic variants of the apolipoprotein E (APOE) gene influence the course of several
neurological diseases. In multiple sclerosis the concentration of APOE in cerebrospinal fluid …

Activation of the innate immune response following myocardial infarction (MI) is essential for
infarct repair. Preclinical models of MI commonly use C57BL/6 mice, which have a type 1 …

Alopecia areata is an inflammatory hair loss disease with a major genetic component. The
presence of focal inflammatory lesions with perifollicular T‐cell infiltrates reflects the …

The immune response is regulated by cytokine network, in which the synergy and
antagonism of particular cytokines must be finely tuned to reach the right outcome. Both …

Background: We describe a simple, non‐invasive mouthwash sampling method for rapid
DNA isolation to detect cytokine gene polymorphisms. In the present paper, interleukin‐1β …

We have investigated separate as well as combined influence of IL-1β TaqI, IL-1ra VNTR
and CTLA-4+ 49 A/G polymorphisms on susceptibility, clinical course and progression of MS …

Susceptibility to multiple sclerosis (MS) may be influenced by the interaction of several
genes within a biological pathway. T cell activation and costimulation may be potentially …

Objective: To determine whether preeclampsia is either associated with or linked to two
polymorphisms in the IL1B gene (IL1B-Taq I and IL1B-511) and one polymorphism in the …

Background: Multiple sclerosis (MS) is an autoimmune disorder, with a considerable genetic
influence on susceptibility and disease course. Cytokines play an important role in MS …

Приведены собственные и литературные данные о полиморфизме генов цитокинов и
их рецепторов, механизмах регуляции экспрессии белковых продуктов генов …