CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

In human cells, three closely related RAS genes, termed HRAS, KRAS, and NRAS, encode
four highly homologous proteins. RAS proteins are small GTPases involved in a broad …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …

Being sessile organisms, plants are ubiquitously exposed to stresses that can affect the DNA
replication process or cause DNA damage. To cope with these problems, plants utilize DNA …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most
patients presenting with advanced stage tumors. About a third of patients do not respond to …

CK2 is a protein kinase involved in several human diseases (ranging from neurological and
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …

Histone deacetylases (HDACs) are epigenetic regulators of chromatin condensation and
decondensation and exert effects on the proliferation and spread of cancer. Thus, HDAC …

Melanoma is deadly, physically impairing, and has ongoing treatment deficiencies. Current
treatment regimens include surgery, targeted kinase inhibitors, immunotherapy, and …