Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases
(NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β …

Gluconeogenesis, a pathway for glucose synthesis from non-carbohydrate substances,
begins with the synthesis of oxaloacetate (OA) from pyruvate and intermediates of citric acid …

Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic syndrome defined through the
dysfunction of pancreatic β-cells driven by a confluence of genetic and environmental …

The liver is a major store of glycogen and is essential in maintaining systemic glucose
homeostasis. In healthy individuals, glycogen synthesis and breakdown in the liver are …

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …

PAR2 promotes impaired glucose uptake and insulin resistance... : Hepatology PAR2 promotes
impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference …

Insulin is a critical hormone that promotes energy storage in various tissues, as well as
anabolic functions. Insulin resistance significantly reduces these responses, resulting in …

Abstract Background and Aims Insulin resistance and poor glycemic control are key drivers
of the development of NAFLD and have recently been shown to be associated with fibrosis …

Background Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo
lipid synthesis. Paradoxically, hepatic insulin resistance (HIR) enhances both …

Auricularia auricula‐judae is an edible fungus with high nutritional value due to abundant
polysaccharides, and is acknowledged as traditional food and medicine in Asia …