Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions
H Deng, Y Han, L Liu, H Zhang, D Liu… - Journal of Medicinal …, 2024 - ACS Publications
As a tripartite cell death switch, B-cell lymphoma protein 2 (Bcl-2) family members precisely
regulate the endogenous apoptosis pathway in response to various cell signal stresses …
regulate the endogenous apoptosis pathway in response to various cell signal stresses …
Anticancer mechanisms of β‐carbolines
S Mishra, A Gupta, S Jain… - Chemical Biology & Drug …, 2024 - Wiley Online Library
Abstract β‐Carboline nucleus is therapeutically valuable in medicinal chemistry for the
treatment of varied number of diseases, most importantly cancer. The potent and wide …
treatment of varied number of diseases, most importantly cancer. The potent and wide …
Discovery of mitochondrion-targeting copper (ii)-plumbagin and-bipyridine complexes as chemodynamic therapy agents with enhanced antitumor activity
HQ Zhang, X Lu, JL Wu, MQ Ou, NF Chen… - Dalton …, 2024 - pubs.rsc.org
Four copper (II)-plumbagin and-bipyridine complexes (Cu1–Cu4) were synthesized as
chemodynamic therapy agents with enhanced antitumor activity. As lipophilic and positively …
chemodynamic therapy agents with enhanced antitumor activity. As lipophilic and positively …
Copper (II) complexes with plumbagin and bipyridines target mitochondria for enhanced chemodynamic cancer therapy
HQ Zhang, X Lu, H Liang, ZF Chen - Journal of Inorganic Biochemistry, 2024 - Elsevier
The combination of mitochondrial targeting and chemodynamic therapy is a promising anti-
cancer strategy. Three mitochondria targeting copper (II) complexes (Cu1–Cu3) with …
cancer strategy. Three mitochondria targeting copper (II) complexes (Cu1–Cu3) with …
Two-Photon Photodegradation of E3 Ubiquitin Ligase Cereblon by a Ru (II) Complex: Inducing Ferroptosis in Cisplatin-Resistant Tumor Cells
X Lin, M Zheng, K Xiong, F Wang, Y Chen… - Journal of Medicinal …, 2024 - ACS Publications
Using photodynamic therapy (PDT) to trigger nonconventional cell death pathways has
provided a new scheme for highly efficient and non-side effects to drug-resistant cancer …
provided a new scheme for highly efficient and non-side effects to drug-resistant cancer …
Discovery of Novel Mcl-1 Inhibitors with a 3-Substituted-1H-indole-1-yl Moiety Binding to the P1–P3 Pockets to Induce Apoptosis in Acute Myeloid Leukemia Cells
H Deng, J Zhang, L Liu, H Zhang, Y Han… - Journal of Medicinal …, 2024 - ACS Publications
Mcl-1 is a main antiapoptotic protein in acute myeloid leukemia (AML) and is used as a
target to develop inhibitors. Currently, potent Mcl-1 inhibitors primarily interact with the P2 …
target to develop inhibitors. Currently, potent Mcl-1 inhibitors primarily interact with the P2 …
Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL-1 with Antitumor Activity
Q Gong, C Li, H Wang, J Cao, Z Li, M Zhou, Y Li… - ACS …, 2024 - ACS Publications
MCL-1, an antiapoptotic member of the BCL-2 family, is dysregulated and overexpressed in
various tumors. In tumors with MCL-1 overexpression, selective inhibitors of MCL-1 are …
various tumors. In tumors with MCL-1 overexpression, selective inhibitors of MCL-1 are …
pH-responsive composite nanomaterial engineered from silica nanoparticles and luminescent mitochondrion-targeted Pt (II) complex as anticancer agent
BA Faizullin, AR Khazieva, KV Kholin… - Journal of Molecular …, 2024 - Elsevier
The present work introduces a pH-dependent adsorption of water-soluble Pt (II) complex
with diimine and alkynylphosphonium ligands ([Pt] 2+) onto a surface of silica nanoparticles …
with diimine and alkynylphosphonium ligands ([Pt] 2+) onto a surface of silica nanoparticles …