All organisms suffer double‐strand breaks (DSBs) in their DNA as a result of exposure to
ionizing radiation. DSBs can also form when replication forks encounter DNA lesions or …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing
dissociation of the TIMELESS-TIPIN complex from the replisome. Here, we show that ROS …

R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand
to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific …

In most organisms, the maturation of nascent RNAs is coupled to transcription. Unlike in
animals, the RNA polymerase II (RNAPII) transcribes microRNA genes (MIRNA s) as long …

R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are
physiological structures that regulate various cellular processes occurring on chromatin …

Ewing sarcoma is an aggressive paediatric cancer of the bone and soft tissue. It results from
a chromosomal translocation, predominantly t (11; 22)(q24: q12), that fuses the N-terminal …

The mechanisms contributing to transcription-associated genomic instability are both
complex and incompletely understood. Although R-loops are normal transcriptional …

R-loops, nucleic acid structures consisting of an RNA–DNA hybrid and displaced single-
stranded (ss) DNA, are ubiquitous in organisms from bacteria to mammals. First described in …

Transcript termination is essential for accurate gene expression and the removal of RNA
polymerase (RNAP) at the ends of transcription units. In bacteria, two mechanisms are …