R-loops are non-B DNA structures that form during transcription when the nascent RNA
anneals to the template DNA strand forming a RNA: DNA hybrid. Understanding the …

Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …

During transcription, the nascent RNA can invade the DNA template, forming extended RNA-
DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …

Background Co-transcriptional R-loops are abundant non-B DNA structures in mammalian
genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing …

RNA molecules, such as long noncoding RNAs (lncRNAs), have critical roles in regulating
gene expression, chromosome architecture, and the modification states of chromatin …

The controlled release of RNA polymerase II (RNAPII) from promoter-proximal pausing
(PPP) sites is critical for transcription elongation in metazoans. We show that the human …

R-loops are structures consisting of an RNA-DNA duplex and an unpaired DNA strand. They
can form during transcription upon nascent RNA “threadback” invasion into the DNA duplex …

R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the
RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R …

Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and
biological processes. The subcellular localization of lncRNAs determines their modes of …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …