We previously identified the heterogeneous ribonucleoprotein SAF-A/hnRNP U as a
substrate for DNA-PK, a protein kinase involved in DNA damage response (DDR). Using …

Although RNA and RNA-binding proteins have been linked to double-strand breaks (DSBs),
little is known regarding their roles in the cellular response to DSBs and, if any, in the repair …

G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

Life cycle delays are beneficial for opportunistic species encountering suboptimal
environments. Many animals display a programmed arrest of development (diapause) at …

Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3
promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify …

Gross chromosomal rearrangements (including translocations, deletions, insertions and
duplications) are a hallmark of cancer genomes and often create oncogenic fusion genes …

R-loops are three-stranded nucleic acid structures composed of an RNA: DNA hybrid and
displaced DNA strand. These structures can halt DNA replication when formed co …

RNA performs diverse functions in cells, directing translation, modulating transcription and
catalyzing enzymatic reactions. Remarkably RNA can also anneal to its genomic template …

R-loops are three-stranded nucleic acid structures that form during transcription, especially
over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells …

Oncogene activation during tumorigenesis generates DNA replication stress, a known driver
of genome rearrangements. In response to replication stress, certain loci, such as common …