Replication–transcription conflicts have been a well-studied source of genome instability for
many years and have frequently been linked to defects in RNA processing. However, recent …

Genetic mutations or environmental agents are major contributors to leukemia and are
associated with genomic instability. R-loops are three-stranded nucleic acid structures …

G-quadruplex or G4 DNA is a non-B secondary DNA structure that comprises a stacked
array of guanine-quartets. Cellular processes such as transcription and replication can be …

Saccharomyces cerevisiae Pif1, an SF1B helicase, has been implicated in both
mitochondrial and nuclear functions. Here we have characterized the preference of Pif1 for …

Mutations or dysregulated expression of NF-kappaB-activating protein (NKAP) family genes
have been found in human cancers. How NKAP family gene mutations promote tumor …

RNA DNA hybrids form in the nuclei and mitochondria of cells as transcription-induced R-
loops or G-quadruplexes, but exist only in the cytosol of virus-infected cells. Little is known …

Several aspects of the mechanism of homologous double-strand break repair remain
unclear. Although intensive efforts have focused on how recombination reactions initiate, far …

Topoisomerases manage the torsional stress associated with the separation of DNA strands
during transcription and DNA replication. Eukaryotic Topoisomerase I (Top1) is a Type IB …

R-loops are stable RNA–DNA hybrids that have been implicated in transcription initiation
and termination, as well as in telomere maintenance, chromatin formation, and genome …

Alterations of DNA repair enzymes and consequential triggering of aberrant DNA damage
response (DDR) pathways are thought to play a pivotal role in genomic instabilities …