Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial intelligence

SZ Alshawwa, AA Kassem, RM Farid, SK Mostafa… - Pharmaceutics, 2022 - mdpi.com
There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

Lipid vesicles: A versatile drug delivery platform for dermal and transdermal applications

IA Chacko, VM Ghate, L Dsouza, SA Lewis - Colloids and Surfaces B …, 2020 - Elsevier
Topical and transdermal application of active pharmaceutical ingredients to the skin is an
attractive strategy being explored by formulation scientists to treat disease conditions rather …

Liposomes for oral delivery of protein and peptide-based therapeutics: Challenges, formulation strategies, and advances

A Jash, A Ubeyitogullari, SSH Rizvi - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Throughout the past decade, there has been a rapid growth in the development of
protein/peptide-based therapeutics. These therapeutics have found widespread applications …

Exploring the impact of physicochemical properties of liposomal formulations on their in vivo fate

B Sheikholeslami, NW Lam, K Dua, M Haghi - Life Sciences, 2022 - Elsevier
Liposomes, vesicles composed of a phospholipid bilayer, are considered a remarkably
advanced drug delivery system due to their unique properties, including their …

Optimization to development of chitosan decorated polycaprolactone nanoparticles for improved ocular delivery of dorzolamide: In vitro, ex vivo and toxicity …

MS Shahab, M Rizwanullah, S Alshehri… - International journal of …, 2020 - Elsevier
The present research work was designed to develop dorzolamide-loaded chitosan-coated
polycaprolactone nanoparticles (DRZ-CS-PCL-NPs) for improved ocular delivery. The …

Nanostructured lipid carrier-based codelivery of raloxifene and naringin: formulation, optimization, in vitro, ex vivo, in vivo assessment, and acute toxicity studies

A Alhalmi, S Amin, Z Khan, S Beg, O Al Kamaly… - Pharmaceutics, 2022 - mdpi.com
This work aimed to develop dual drug-loaded nanostructured lipid carriers of raloxifene and
naringin (RLX/NRG NLCs) for breast cancer. RLX/NRG NLCs were prepared using …

Oral delivery of psoralidin by mucoadhesive surface-modified bilosomes showed boosted apoptotic and necrotic effects against breast and lung cancer cells

RA Youness, AM Al-Mahallawi, FH Mahmoud, H Atta… - Polymers, 2023 - mdpi.com
This study aims to design and optimize chitosan-coated bilosomal formulations loaded with
psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and …

Lipid nanovesicles for biomedical applications:'What is in a name'?

AC Apolinário, L Hauschke, JR Nunes… - Progress in lipid research, 2021 - Elsevier
Vesicles, generally defined as self-assembled structures formed by single or multiple
concentric bilayers that surround an aqueous core, have been widely used for biomedical …

Intranasal zolmitriptan-loaded bilosomes with extended nasal mucociliary transit time for direct nose to brain delivery

MM El Taweel, MH Aboul-Einien, MA Kassem… - Pharmaceutics, 2021 - mdpi.com
This study aimed at delivering intranasal zolmitriptan directly to the brain through
preparation of bilosomes incorporated into a mucoadhesive in situ gel with extended nasal …

Bilosomes as nanoplatform for oral delivery and modulated in vivo antimicrobial activity of lycopene

R Binsuwaidan, AA Sultan, WA Negm, NGM Attallah… - Pharmaceuticals, 2022 - mdpi.com
Owing to the disseminating resistance among pathogenic bacteria, especially Klebsiella
pneumoniae, there is a high need for alternate compounds with antibacterial activity. Herein …