Psoralen is the principal bioactive component in the dried fruits of Cullen corylifolium (L.)
Medik (syn. Psoralea corylifolia L), termed “Buguzhi” in traditional Chinese medicine (TCM) …

Dengue virus (DENV) is a significant cause of morbidity and mortality in tropical and
subtropical regions, causing hundreds of millions of infections each year. Infections range …

Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly
infectious and profoundly virulent diseases may be caused in combat personnel or in civilian …

Dengue fever, caused by dengue viruses (DENV 1–4) is a leading cause of illness and
death in the tropics and subtropics. Therefore, an effective vaccine is urgently needed …

Psoralens are photoreactive compounds that cross-link pyrimidines after exposure to UVA
radiation. In this experiment, we tested the protective efficacy of a psoralen-inactivated …

Dengue viruses (DENVs) are among the most rapidly and efficiently spreading arboviruses.
WHO recently estimated that about half of the world's population is now at risk for DENV …

Inactivated whole-cell vaccines present a full repertoire of antigens to the immune system.
Formalin treatment, a standard method for microbial inactivation, can modify or destroy …

High consequence human pathogenic viruses must be handled at biosafety level 2, 3 or 4
and must be rendered non-infectious before they can be utilized for molecular or …

Dengue virus (DENV), a member of the Flaviviridae family, can be transmitted to humans
through the bite of infected Aedes mosquitoes. The incidence of dengue has increased …

Dengue fever is caused by the mosquito-borne dengue virus (DENV) serotypes 1-4, and is
the most common arboviral infection of humans in subtropical and tropical regions of the …