The immune microenvironment is a critical driver and regulator of leukemic progression and
hematological disease. Recent investigations have demonstrated that multiple immune …

Simple Summary Despite remarkable progress in the outcome of childhood acute myeloid
leukemia (AML), risk of relapse and refractory diseases remains high. Treatment of the …

Blockade of inhibitory receptors (IRs) is one of the most effective immunotherapeutic
approaches to treat cancer. Dysfunction of miRNAs is a major cause of aberrant expression …

Chimeric antigen receptor (CAR) T cells have shown remarkable success in treating
hematologic cancers. However, this efficacy has yet to translate to treatment in solid tumors …

The surfaces of all living organisms and most secreted proteins share a common feature:
They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all …

Immune checkpoint receptor signaling pathways constitute a prominent class of “immune
synapse,” a cell-to-cell connection that represses T-lymphocyte effector functions. As a …

Galectin-9 is one of the key proteins employed by a variety of human malignancies to
suppress anti-cancer activities of cytotoxic lymphoid cells and thus escape immune …

Dendritic cell (DC) based immunotherapy is a promising approach to clinical cancer
treatment. miRNAs are a class of small non-coding RNA molecules that bind to RNAs to …

Natural killer (NK) cells are lymphoid cells of innate immunity that take important roles in
immune surveillance. NK cells are considered as a bridge between innate and adaptive …

Natural killer (NK) cells are potent innate immune system effector lymphocytes armed with
multiple mechanisms for killing cancer cells. Given the dynamic roles of NK cells in tumor …