A brain-targeted approach to ameliorate memory disorders in a sporadic Alzheimer's disease mouse model via intranasal luteolin-loaded nanobilosomes

MA Elsheikh, YA El-Feky, MM Al-Sawahli, ME Ali… - Pharmaceutics, 2022 - mdpi.com
Impaired memory and cognitive function are the main features of Alzheimer's disease (AD).
Unfortunately, currently available treatments cannot cure or delay AD progression …

Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status

S Gorantla, G Singhvi, VK Rapalli, T Waghule… - Therapeutic …, 2020 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that is characterized by
synovial inflammation, cellular infiltration in joints which leads to progressive joint …

Development and evaluation of the effect of ethanol and surfactant in vesicular carriers on Lamivudine permeation through the skin

K Sudhakar, V Mishra, S Jain, NC Rompicherla… - International journal of …, 2021 - Elsevier
The skin embodies a relatively large and readily accessible surface area to absorb a drug
through a non-invasive procedure. The vesicular carrier systems such as liposomes …

Sonophoresis-assisted transdermal delivery of antimigraine-loaded nanolipomers: Radio-tracking, histopathological assessment and in-vivo biodistribution study

MA Tawfik, MM Eltaweel, MM Farag… - International Journal of …, 2023 - Elsevier
Migraine is a disabling neurovascular polygenic disorder affecting life quality with escorted
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …

Transethosome‐Based Topical Administration Systems with Enhanced Penetration and Dual Actions for Treating EGFR‐Overexpressed Cutaneous Squamous Cell …

W Wang, PH Tham, C Ding, P Huang… - Advanced Functional …, 2024 - Wiley Online Library
Epidermal growth factor receptor (EGFR)‐overexpressing cutaneous squamous cell
carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk …

Formulation development and in vitro–in vivo assessment of protransfersomal gel of anti-resorptive drug in osteoporosis treatment

S Gyanewali, P Kesharwani, A Sheikh… - International Journal of …, 2021 - Elsevier
Osteoporosis is a major cause of morbidity, mortality, and economic burden worldwide.
Despite being an effective in combating the bone-deteriorating disorders, bisphosphonates …

Transethosome: An ultra-deformable ethanolic vesicle for enhanced transdermal drug delivery

A Raj, K Dua, RS Nair, CS Chandran… - Chemistry and Physics of …, 2023 - Elsevier
Drug delivery through the skin improves solubility, bioavailability, and unwanted systemic
side effects of the drug. The selection of a suitable carrier is a challenging process. The …

Baicalin loaded transethosomes for rheumatoid arthritis: Development, characterization, pharmacokinetic and pharmacodynamic evaluation

SN Adin, I Gupta, M Aqil, M Mujeeb - Journal of drug delivery science and …, 2023 - Elsevier
The present research study limns the preparation of Baicalin-loaded transethosomes (BCL-
TE) to improve BCL solubility, bioavailability and permeation through skin layers for …

[HTML][HTML] Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for …

RMA Abd-Elal, AM Essawy, MA Salem… - International Journal of …, 2023 - Elsevier
Duloxetine hydrochloride (DUL) is a BCS class-II antidepressant drug, acting via serotonin
and norepinephrine reuptake inhibition. Despite high oral absorption, DUL suffers limited …

Size-dependent absorption through stratum corneum by drug-loaded liposomes

J Liu, A Zheng, B Peng, Y Xu, N Zhang - Pharmaceutical Research, 2021 - Springer
Purpose Topical treatment of various skin disorders requires drug absorption and
penetration through the stratum corneum (SC) into the epidermis and dermis tissues. The …