Evolutionary landscapes of host-virus arms races
JL Tenthorey, M Emerman… - Annual Review of …, 2022 - annualreviews.org
Vertebrate immune systems suppress viral infection using both innate restriction factors and
adaptive immunity. Viruses mutate to escape these defenses, driving hosts to counterevolve …
adaptive immunity. Viruses mutate to escape these defenses, driving hosts to counterevolve …
Restriction of HIV-1 and other retroviruses by TRIM5
BK Ganser-Pornillos, O Pornillos - Nature Reviews Microbiology, 2019 - nature.com
Mammalian cells express a variety of innate immune proteins—known as restriction factors—
which defend against invading retroviruses such as HIV-1. Two members of the tripartite …
which defend against invading retroviruses such as HIV-1. Two members of the tripartite …
[HTML][HTML] Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
P Bercier, QQ Wang, N Zang, J Zhang, C Yang… - Cancer Discovery, 2023 - AACR
PML nuclear bodies (NB) are disrupted in PML-RARA–driven acute promyelocytic leukemia
(APL). Arsenic trioxide (ATO) cures 70% of patients with APL, driving PML-RARA …
(APL). Arsenic trioxide (ATO) cures 70% of patients with APL, driving PML-RARA …
[HTML][HTML] TRIM21/Ro52-roles in innate immunity and autoimmune disease
TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …
[HTML][HTML] MuRF1/TRIM63, master regulator of muscle mass
D Peris-Moreno, D Taillandier, C Polge - International journal of …, 2020 - mdpi.com
The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …
important roles during skeletal muscle atrophy. Since then, numerous studies have been …
[HTML][HTML] Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
SH Park, J Han, BC Jeong, JH Song, SH Jang… - Nature Structural & …, 2023 - nature.com
Defects in plasma membrane repair can lead to muscle and heart diseases in humans.
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …
Structural determinants of TRIM protein function
D Esposito, MG Koliopoulos… - Biochemical Society …, 2017 - portlandpress.com
Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of Really Interesting
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …
New Gene (RING) E3 ubiquitin ligases and contribute to the regulation of numerous cellular …
[HTML][HTML] SPATA2 links CYLD to LUBAC, activates CYLD, and controls LUBAC signaling
The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its
function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the …
function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the …
[HTML][HTML] To TRIM the immunity: from innate to adaptive immunity
W Yang, Z Gu, H Zhang, H Hu - Frontiers in immunology, 2020 - frontiersin.org
The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in
various biological processes, especially in regulating a wide range of signaling pathways …
various biological processes, especially in regulating a wide range of signaling pathways …
[HTML][HTML] The TRIMendous role of TRIMs in virus–host interactions
The innate antiviral response is integral in protecting the host against virus infection. Many
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …