Leukocyte migration from the vascular compartment is critical for normal lymphocyte
recirculation in specific tissues and immune response in inflammatory locations. Leukocyte …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

CAMILLA is a basket trial (NCT03539822) evaluating cabozantinib plus the ICI durvalumab
in chemorefractory gastrointestinal cancer. Herein, are the phase II colorectal cohort results …

Oral carcinoma is the sixth most common cancer globally, with one death occurring every
hour. Focal adhesion kinase (FAK) is an intercellular protein tyrosine kinase, a key indicator …

Abstract Ethnopharmacological relevance Zhuidu Formula (ZDF) is composed of triptolide,
cinobufagin and paclitaxel, which are the active ingredients of Tripterygium wilfordii Hook. F …

The mesenchymal stromal/stem cells (MSCs) are known to secrete pleiotropic paracrine
factors, contributing to tissue regeneration. This unique ability makes MSCs promising …

There is growing evidence that various ATP-binding cassette (ABC) transporters contribute
to the growth and development of tumors, but relatively little is known about how the ABC …

Background: The pathogenic genes of colorectal cancer (CRC) have not yet been fully
elucidated, and there is currently a lack of effective therapeutic targets. This study used …

Distant metastasis is a major cause of treatment failure in cancer patients and a key
challenge to improving cancer care today. We hypothesized that enhancing anti-cancer …

Pancreatic ductal adenocarcinoma (PDAC) is among the leading causes of cancer-related
deaths worldwide. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase often …