Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

MT El-Saadony, T Yang, SA Korma, M Sitohy… - Frontiers in …, 2023 - frontiersin.org
The yellow polyphenolic pigment known as curcumin, originating from the rhizome of the
turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, as well as …

The role of curcumin in cancer treatment

V Zoi, V Galani, GD Lianos, S Voulgaris, AP Kyritsis… - Biomedicines, 2021 - mdpi.com
Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, Curcuma longa
which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated …

[HTML][HTML] Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

Y Cheng, X Ma, Y Wei, XW Wei - … et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

[HTML][HTML] Curcuma longa (Turmeric): Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles—A review

EJ Iweala, ME Uche, ED Dike, LR Etumnu… - Pharmacological …, 2023 - Elsevier
Introduction Curcuma longa, popularly known as Turmeric, is a rhizomatous herbaceous
perennial plant used in folk medicine for the treatment, prevention, and management of …

Curcumin, inflammation, and chronic diseases: how are they linked?

Y He, Y Yue, X Zheng, K Zhang, S Chen, Z Du - Molecules, 2015 - mdpi.com
It is extensively verified that continued oxidative stress and oxidative damage may lead to
chronic inflammation, which in turn can mediate most chronic diseases including cancer …

The multifaceted role of curcumin in cancer prevention and treatment

MK Shanmugam, G Rane, MM Kanchi, F Arfuso… - Molecules, 2015 - mdpi.com
Despite significant advances in treatment modalities over the last decade, neither the
incidence of the disease nor the mortality due to cancer has altered in the last thirty years …

Curcumin: recent advances in the development of strategies to improve oral bioavailability

KZ Sanidad, E Sukamtoh, H Xiao… - Annual review of …, 2019 - annualreviews.org
Substantial human and preclinical studies have shown that curcumin, a dietary compound
from turmeric, has a variety of health-promoting effects including but not limited to …

Curcumin against prostate cancer: current evidence

D Termini, DJ Den Hartogh, A Jaglanian, E Tsiani - Biomolecules, 2020 - mdpi.com
Cancer is a condition characterized by remarkably enhanced rates of cell proliferation
paired with evasion of cell death. These deregulated cellular processes take place following …