GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABAAR γ1 subunit during aging

LC Robinson, O Barat, JG Mellott - Neurobiology of aging, 2019 - Elsevier
Age-related hearing loss may result, in part, from declining levels of γ-amino butyric acid
(GABA) in the aging inferior colliculus (IC). An upregulation of the GABA AR γ 1 subunit …

Inferior collicular cells that project to the auditory thalamus are increasingly surrounded by perineuronal nets with age

AM Mafi, MG Russ, LN Hofer, VQ Pham, JW Young… - Neurobiology of …, 2021 - Elsevier
The age-related loss of GABA in the inferior colliculus (IC) likely plays a role in the
development of age-related hearing loss. Perineuronal nets (PNs), specialized aggregates …

Nicotine reduces age-related changes in cortical neural oscillations without affecting auditory brainstem responses

JA Rumschlag, JW Lovelace, J Kokash, A Hussain… - Neurobiology of …, 2022 - Elsevier
Neural oscillations at specific frequency bands are associated with cognitive functions and
can identify abnormalities in cortical dynamics. In this study, we analyzed EEG signals …

Hybrid auditory fMRI: In pursuit of increasing data acquisition while decreasing the impact of scanner noise

M Heard, X Li, YS Lee - Journal of Neuroscience Methods, 2021 - Elsevier
Background Two challenges in auditory fMRI include the loud scanner noise during sound
presentation and slow data acquisition. Here, we introduce a new auditory imaging protocol …

The Speech Envelope Following Response in Normal and Hearing Impaired Listeners

T Wartenberg, M Garrett, S Verhulst - BioRxiv, 2022 - biorxiv.org
The aim of this work was to investigate the perceptual relevance of the frequency following
response to the syllable/da/for speech intelligibility in noise based on age and hearing …

[HTML][HTML] Model-predicted balance between neural excitation and inhibition was maintained despite of age-related decline in sensory evoked local field potential in rat …

S Kang, Y Hayashi, M Bruyns-Haylett… - Frontiers in Systems …, 2020 - frontiersin.org
The balance between neural excitation and inhibition has been shown to be crucial for
normal brain function. However, it is unclear whether this balance is maintained through …

Changes in Cortical Directional Connectivity during Difficult Listening in Younger and Older Adults

B Soleimani, IMD Karunathilake, P Das, SE Kuchinsky… - bioRxiv, 2023 - biorxiv.org
One way to investigate the mechanisms that underlie speech comprehension under difficult
listening conditions is via cortical connectivity. The innovative Network Localized Granger …

Neural signatures of disordered multi-talker speech perception in adults with normal hearing

A Parthasarathy, KE Hancock, K Bennett, V DeGruttola… - bioRxiv, 2019 - biorxiv.org
In social settings, speech waveforms from nearby speakers mix together in our ear canals.
The brain unmixes the attended speech stream from the chorus of background speakers …

Contributions of low-and high-frequency sensorineural hearing deficits to speech intelligibility in noise

S Verhulst, A Warzybok - BioRxiv, 2018 - biorxiv.org
This study investigates the role of hearing sensitivity, age and supra-threshold hearing to
speech recognition in quiet, stationary, and modulated noise. Three participant groups were …

[HTML][HTML] Sensory representations and pupil-indexed listening effort provide complementary contributions to multi-talker speech intelligibility

JR McHaney, KE Hancock, DB Polley, A Parthasarathy - bioRxiv, 2023 - ncbi.nlm.nih.gov
Optimal speech perception in noise requires successful separation of the target speech
stream from multiple competing background speech streams. The ability to segregate these …