The last decade has witnessed unparalleled advances in our understanding of the
complexity of the oral microbiome and the compositional changes that occur in subgingival …

Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as
dental caries and periodontitis, two of the most prevalent microbially induced disorders …

Periodontitis is one of the most common dental diseases. Compared with healthy
periodontal tissues, the immune microenvironment plays the key role in periodontitis by …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

Abstract Interleukin (IL)-1β, a pro-inflammatory cytokine, was elevated and participates in
periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

Bone remodeling in the adult skeleton facilitates the removal and replacement of damaged
and old bone to maintain bone quality. Tight coordination of bone resorption and bone …

Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell
RNA-seq experiments have provided new insight into how resident cells and infiltrating …

The influence of microorganisms growing as sessile communities in a large number of
human infections has been extensively studied and recognized for 30–40 years, therefore …