Despite the long-standing observation of vast neuronal loss in Alzheimer's disease (AD) our
understanding of how and when neurons are eliminated is incomplete. While previous …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Alzheimer's disease (AD) is characterized by the selective vulnerability of specific neuronal
populations, the molecular signatures of which are largely unknown. To identify and …

Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

Abstract In 2016 the World Health Organization reported 39% of the world's adult population
(over 18 y) was overweight, with western countries such as Australia and the United States …

Background The order and magnitude of pathologic processes in Alzheimer's disease are
not well understood, partly because the disease develops over many years. Autosomal …

The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …