RNA-binding proteins as important regulators of long non-coding RNAs in cancer
The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among
which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile …
which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile …
PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer
W Yu, Y Hua, H Qiu, J Hao, K Zou, Z Li, S Hu… - Cell death & …, 2020 - nature.com
PD-L1 is overexpressed in tumor cells and contributes to cancer immunoevasion. However,
the role of the tumor cell-intrinsic PD-L1 in cancers remains unknown. Here we show that PD …
the role of the tumor cell-intrinsic PD-L1 in cancers remains unknown. Here we show that PD …
BPDE, the Migration and Invasion of Human Trophoblast Cells, and Occurrence of Miscarriage in Humans: Roles of a Novel lncRNA-HZ09
M Dai, W Huang, X Huang, C Ma, R Wang… - Environmental …, 2023 - ehp.niehs.nih.gov
Background: Recurrent miscarriage (RM) affects 1%–3% of pregnancies. However, in
almost 50% of cases, the cause is unknown. Increasing evidence have shown that benzo (a) …
almost 50% of cases, the cause is unknown. Increasing evidence have shown that benzo (a) …
The combined regulation of long non-coding RNA and RNA-binding proteins in atherosclerosis
Y Ding, R Yin, S Zhang, Q Xiao, H Zhao… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a complex disease closely related to the function of endothelial cells
(ECs), monocytes/macrophages, and vascular smooth muscle cells (VSMCs). Despite a …
(ECs), monocytes/macrophages, and vascular smooth muscle cells (VSMCs). Despite a …
Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive …
Z Xu, P Tian, J Guo, C Mi, T Liang, J Xie… - Science of The Total …, 2021 - Elsevier
Environmental BaP (benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-
dihydrodiol-9, 10-epoxide) inhibit proliferation of human villous trophoblast cells, which …
dihydrodiol-9, 10-epoxide) inhibit proliferation of human villous trophoblast cells, which …
Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblastic cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway
T Liang, J Xie, J Zhao, W Huang, Z Xu, P Tian… - Cell Biology and …, 2021 - Springer
Normal pregnancy is essential for human reproduction. However, environmental BaP
(benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-dihydrodiol-9, 10 …
(benzo (a) pyrene) and its metabolite BPDE (benzo (a) pyrene-7, 8-dihydrodiol-9, 10 …
Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion
C Lyu, T Ni, Y Guo, T Zhou, ZJ Chen, J Yan… - Cell …, 2023 - Wiley Online Library
Insufficient extravillous trophoblast (EVT) invasion during early placentation has been
shown to contribute to recurrent pregnancy loss (RPL). However, the regulatory factors …
shown to contribute to recurrent pregnancy loss (RPL). However, the regulatory factors …
Upregulation of PUM1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR
Y Zhang, XY He, S Qin, HQ Mo, X Li, F Wu, J Zhang… - Molecular Therapy, 2020 - cell.com
Pumilio (PUM) proteins are members of a highly conserved RNA-binding protein family that
posttranscriptionally regulate gene expression in many organisms. However, their roles in …
posttranscriptionally regulate gene expression in many organisms. However, their roles in …
Novel lncRNA‐HZ04 promotes BPDE‐induced human trophoblast cell apoptosis and miscarriage by upregulating IP3R1/CaMKII/SGCB pathway by competitively …
W Huang, M Dai, T Qiu, T Liang, J Xie, C Mi… - The FASEB …, 2021 - Wiley Online Library
Normal pregnancy is essential for human reproduction. However, BaP (benzo (a) pyrene)
and its metabolite BPDE (benzo (a) pyrene‐7, 8‐dihydrodiol‐9, 10‐epoxide) could cause …
and its metabolite BPDE (benzo (a) pyrene‐7, 8‐dihydrodiol‐9, 10‐epoxide) could cause …
Environmental pollutant benzo [a] pyrene induces recurrent pregnancy loss through promoting apoptosis and suppressing migration of extravillous trophoblast
Y Ye, S Jiang, C Zhang, Y Cheng… - BioMed research …, 2020 - Wiley Online Library
Objects. To investigate the effects of environmental pollutant benzo (a) pyrene (BaP) and its
metabolite benzo [a] pyrene‐7, 8‐diol‐9, 10‐epoxide (BPDE) on human trophoblasts and on …
metabolite benzo [a] pyrene‐7, 8‐diol‐9, 10‐epoxide (BPDE) on human trophoblasts and on …