Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Protein S-palmitoylation is a covalent and reversible lipid modification that specifically
targets cysteine residues within many eukaryotic proteins. In mammalian cells, the …

Aims: Impaired fatty acid oxidation (FAO) in mitochondria of hepatocytes causes lipid
accumulation and excessive production of reactive oxygen species (ROS) and oxidative …

S-acylation is a widespread lipidation form in eukaryotes in which various fatty acids can be
covalently attached to specific cysteine residues. However, due to the low reactivity of the …

Background The identification of pathogenic mutations in Alzheimer's disease (AD) causal
genes led to a better understanding of the pathobiology of AD. Familial Alzheimer's disease …

Despite the remarkable clinical success of immunotherapy and molecular targeted therapy
in patients with advanced tumors, chemotherapy remains the most commonly used …

Epithelial ovarian cancer (EOC) exhibits strong dependency on the tricarboxylic acid (TCA)
cycle and oxidative phosphorylation to fuel anabolic process. Here, we show that malate …

Constitutive activation of the transcription factor STAT3 (signal transducer and activator of
transcription 3) contributes to the malignancy of many cancers such as hepatocellular …

Dysfunction of glutamatergic synaptic plasticity in basolateral amygdala (BLA) constitutes a
critical pathogenic mechanism underlying the depression-like behaviors induced by chronic …

Background Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of
cancer-related death across the world with the limited efficiency and response rate of …