Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence
the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have …

The signals and structure of the tissues in which leukocytes reside critically mould leukocyte
function and development and have challenged our fundamental understanding of how to …

Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms
underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential …

Abstract Purpose of Review To examine the epidemiological data on obesity and leukemia;
evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common bone marrow
abnormality induced by age‐related DNA mutations, which give rise to proinflammatory …

Knowledge on the myeloproliferative neoplasms (MPNs)–polycythemia vera (PV), essential
thrombocythemia (ET), primary myelofibrosis (PMF)–has accumulated since the discovery of …

OBJECTIVE Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related
accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion …

Purpose: Clonal hematopoiesis (CH) is thought to be the origin of myeloid neoplasms (MN).
Yet, our understanding of the mechanisms driving CH progression to MN and clinical risk …

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …

During aging, blood cell production becomes dominated by a limited number of variant
hematopoietic stem cell (HSC) clones. Differentiated progeny of variant HSCs are thought to …