Since the first report of clonidine, an α2-adrenoceptor agonist, the indications for this class of
drugs have continued to expand. In December 1999, dexmedetomidine was approved as …

Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well
as in chronic pain therapy because it has both anaesthetic and analgesic‐sparing activity …

Background This study determined the responses to increasing plasma concentrations of
dexmedetomidine in humans. Methods Ten healthy men (20-27 yr) provided informed …

The hemodynamic response to the stress of laryngoscopy and endotracheal intubation does
not present a problem for most patients. However, patients with cardiovascular or cerebral …

We tested dexmedetomidine, an α 2 agonist that decreases heart rate, blood pressure, and
plasma norepinephrine concentration, for its ability to attenuate stress responses during …

The effects of the new, highly selective alpha 2-adrenergic agonist, dexmedetomidine, were
studied in a randomized, placebo-controlled, double-blind trial in 24 ASA I patients …

PURPOSE: To investigate the effects of α2-adrenergic agonists on perioperative mortality
and cardiovascular complications in adults undergoing surgery. METHODS: MEDLINE …

The analgesic efficacy of dexmedetomidine (DEX)—a novel α 2-adrenoceptor agonist—was
studied in man. Single intravenous doses of fentanyl (FEN; 2 μg/kg), DEX (0.25, 0.50 and 1.0 …

Background: Dexmedetomidine, an α-2 adrenoreceptor agonist, is gaining popularity for its
sympatholytic, sedative, anaesthetic sparing and haemodynamic stabilising properties …

Background Alpha 2-adrenergic agonists decrease sympathetic tone with ensuing
attenuation of neuroendocrine and hemodynamic responses to anesthesia and surgery. The …