Introduction of new tools for chemical biology research on microbial metabolites

H Osada - Bioscience, biotechnology, and biochemistry, 2010 - jstage.jst.go.jp
Recently, high-throughput screening (HTS) has become the mainstream technique for drug
discovery. Compounds that are synthesized by combinatorial chemistry might be more …

Latanoprost/timolol fixed combination for the treatment of glaucoma

AGP Konstas, MC Mocan, A Katsanos… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Glaucoma is a multifactorial optic neuropathy that can lead to progressive and
irreversible loss of vision. Today there are> 60 million glaucoma patients worldwide, and this …

Twenty-four–hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combination

AGP Konstas, P Papapanos, I Tersis, D Houliara… - Ophthalmology, 2003 - Elsevier
PURPOSE: To evaluate the efficacy and safety of commercially available latanoprost
0.005% given every evening versus timolol 0.5% and dorzolamide 2% fixed combination …

The efficacy and safety of the timolol/dorzolamide fixed combination vs latanoprost in exfoliation glaucoma

AGP Konstas, VP Kozobolis, I Tersis, J Leech… - Eye, 2003 - nature.com
Purpose To evaluate the safety and efficacy of the timolol/dorzolamide fixed combination
vslatanoprost 0.005% in exfoliation glaucoma patients. Methods We randomized in an …

Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%

AGP Konstas, VP Kozobolis, N Lallos… - Eye, 2004 - nature.com
Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol
maleate 0.5% and dorzolamide 2%/timolol maleate 0.5% | Eye Skip to main content Thank …

Comparison of brimonidine with latanoprost in the adjunctive treatment of glaucoma

ST Simmons, TW Samuelson… - Clinical …, 2000 - Elsevier
OBJECTIVE: This study compared brimonidine with latanoprost as adjunctive therapy for the
treatment of open-angle glaucoma and ocular hypertension. BACKGROUND: Patients with …

Safety and efficacy of bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% fixed combination

DG Day, ED Sharpe, CJ Beischel… - European journal of …, 2005 - journals.sagepub.com
Purpose To determine the efficacy and safety of bimatoprost given every evening versus the
dorzolamide/timolol fixed combination (DTFC) given twice daily in open-angle glaucoma …

Effectiveness and safety of dorzolamide–timolol alone or combined with latanoprost in open-angle glaucoma or ocular hypertension

MR Lesk, T Koulis, F Sampalis… - Annals of …, 2008 - journals.sagepub.com
BACKGROUND: Treatment of glaucoma is aimed at reducing intraocular pressure (IOP) to
prevent further damage to the optic nerve. For patients who do not respond to monotherapy …

Timolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open-angle glaucoma or …

DG Day, PN Schacknow, M Wand, ED Sharpe… - American journal of …, 2003 - Elsevier
OBJECTIVE: To compare the efficacy and safety of timolol 0.5%/dorzolamide 2% fixed
combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily. DESIGN …

Combination of brimonidine and timolol for topical ophthalmic use

CM Chang, GJ Beck, CC Pratt… - US Patent 7,642,258, 2010 - Google Patents
US7642258B2 - Combination of brimonidine and timolol for topical ophthalmic use - Google
Patents US7642258B2 - Combination of brimonidine and timolol for topical ophthalmic use …