Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

BACKGROUND & AIMS: During tumorigenesis, loss of rapid messenger RNA (mRNA)
decay allows for overexpression of cancer-associated genes. The RNA-binding proteins Hu …

Background Aspirin inhibits colorectal carcinogenesis. In a randomised double-blind
placebo-controlled trial, daily soluble aspirin significantly reduced recurrence of colorectal …

Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …

AIM: To explore the activation of signal transduction pathways related with the
carcinogenesis of sporadic colon cancers. METHODS: A gene array monitoring the …

There is now substantial evidence for the role of cyclooxygenase (COX)‐2 in causation and
prevention of cancer. Selective COX‐2 inhibitors (coxibs) were considered attractive …

Tetrandrine (TET) exhibits biological activities, including anticancer activity. In Chinese
medicine, TET has been used to treat hypertensive and arrhythmic conditions and has been …

Background The exact etiologic mechanisms leading to the formation of nasal polyps have
remained largely obscure. A key phenomenon of this specific type of chronic inflammatory …

The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the
majority of cancers overexpressing COX-2; however, the role of COX-2 in the development …