Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

The impact of vascular risk factors on cognitive function has garnered much interest in recent
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …

Accumulating evidence suggests that cerebrovascular dysfunction is an important factor in
the pathogenesis of Alzheimer's disease (AD). Using aged (∼ 16 months) amyloid precursor …

Aging is associated with cerebrovascular dysregulation, which may underlie the increased
susceptibility to ischemic stroke and vascular cognitive impairment occurring in the elder …

Cerebrovascular complications make diabetic patients 2-6 times more susceptible to a
stroke event and this risk is magnified in younger individuals and in patients with …

The study of reactive oxygen species (ROS) and oxidative stress remains a very active area
of biological research, particularly in relation to cellular signaling and the role of ROS in …

Cerebral small vessel disease (SVD) is a major contributor to stroke, and a leading cause of
cognitive impairment and dementia. Despite the devastating effects of cerebral SVD, the …

The incidence of diabetes has more than doubled in the United States in the last 30 years
and the global disease rate is projected to double by 2030. Cognitive impairment has been …

Cerebral small vessel disease (CSVD) is a wide term describing the condition affecting
perforating arterial branches as well as arterioles, venules, and capillaries. Cerebral …

Metabolic diseases including obesity, insulin resistance and diabetes have profound effects
on cerebral circulation. These diseases not only affect the architecture of cerebral blood …