Highlights•NK cells play a critical role in cancer immune surveillance.•NK cellular therapy is
safe but has some limitations.•Genetic engineering strategies are being employed to …

Chimeric antigen receptor (CAR) T-cells targeting CD19 demonstrated remarkable efficacy
for the treatment of B-cell malignancies. The development of CAR T-cells against T-cell …

Therapies based on immune cells have been applied for diseases ranging from cancer to
diabetes. However, the viral and electroporation methods used to create cytoreagents are …

We developed an innovative and efficient, feeder-free culture method to genetically modify
and expand peripheral blood-derived NK cells with high proliferative capacity, while …

Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical
for the development of immunotherapies aimed to restore and stimulate effective antitumor …

Chemokines are small chemotactic molecules that play key roles in physiological and
pathological conditions. Upon signaling via their specific receptors, chemokines regulate …

Despite of a multitude of excellent studies, the regulatory role of natural killer (NK) cells in
the pathogenesis of inflammatory cardiac disease is greatly underappreciated. Clinical …

In recent decades, a new method of cellular immunotherapy was introduced based on
engineering and empowering the immune effector cells. In this type of immunotherapy, the …

Background: Chimeric antigen receptor (CAR)-modified T cells have successfully harnessed
T cell immunity against malignancies, but they are by no means the only cell therapies in …

Primary human natural killer (NK) cells recognize and subsequently eliminate virus infected
cells, tumor cells, or other aberrant cells. However, cancer cells are able to develop tumor …