Diabetes mellitus is increasing at an alarming rate and has become a global challenge.
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …

Context Chronic systemic inflammation in obesity originates from local immune responses in
visceral adipose tissue. However, assessment of a broad range of inflammation-mediating …

Background & Aims While it is widely accepted that obesity is associated with low-grade
systemic inflammation, the molecular origin of the inflammation remains unknown. Here, we …

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …

Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases
many inflammatory mediators. The source of these mediators within adipose tissue is not …

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and,
therefore, biological processes in different tissues. A major function of miRNAs in adipose …

Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated
from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic …

The frequency of obesity is enormously growing worldwide. Obesity results when energy
intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of …

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …